時(shí)　間：2018年9月6日（周四）15:00

地　點(diǎn)：武漢大學(xué)醫(yī)學(xué)部行政樓（白宮）三樓國(guó)際報(bào)告廳

主講人：Philippa Marrack教授 美國(guó)科學(xué)院院士

題　目：B cell heterogeneity

主講人簡(jiǎn)介：

Philippa Marrack是世界著名的免疫學(xué)研究者，她在T細(xì)胞領(lǐng)域的開(kāi)創(chuàng)性工作使人類對(duì)免疫系統(tǒng)、疫苗、HIV和其他免疫疾病的本質(zhì)有了更加深入的認(rèn)知。

四十多年來(lái)，她和丈夫John Kappler一直專注于揭示免疫系統(tǒng)的奧秘：當(dāng)免疫系統(tǒng)工作時(shí)，它如何保護(hù)我們免受外部威脅？當(dāng)免疫系統(tǒng)發(fā)生故障時(shí)，它如何導(dǎo)致自身免疫和過(guò)敏？他們鑒定并分離了T細(xì)胞受體——免疫應(yīng)答的主要前哨分子；他們發(fā)現(xiàn)了身體如何制造和選擇有效的T細(xì)胞，這些T細(xì)胞能夠識(shí)別和攻擊潛在的有害外來(lái)抗原，同時(shí)不攻擊自身組織；他們還發(fā)現(xiàn)了超抗原，這些超抗原毒素能引起如中毒性休克綜合癥和食物中毒等嚴(yán)重的免疫應(yīng)答疾病。

Philippa Marrack出生于英國(guó)，獲劍橋大學(xué)生物科學(xué)哲學(xué)博士學(xué)位，發(fā)表了超過(guò)450篇同行評(píng)議的期刊文章。她于1989年入選美國(guó)國(guó)家科學(xué)院院士，1997年入選英國(guó)皇家學(xué)會(huì)的會(huì)員，2015年入選國(guó)家婦女名人堂。Marrack同時(shí)入選了美國(guó)藝術(shù)與科學(xué)院、美國(guó)醫(yī)學(xué)研究院院士。她和丈夫一起還獲得了包括路易莎?格羅斯?霍維茨獎(jiǎng)和沃爾夫醫(yī)學(xué)獎(jiǎng)在內(nèi)的許多高聲望榮譽(yù)。

Brief Introduction of Professor Philippa Marrack

Philippa Marrack is a world-renowned immunology researcher whose groundbreaking work on T-cells has impacted the health of people across the world. Her findings shape medicine’s current understanding of the human immune system, vaccines, HIV, and other immune disorders.

For more than four decades together with her husband, John Kappler, she has, and continues to, unraveled the mysteries of the immune system; how it protects us from external threats when it is working and how it can lead to autoimmunity and allergies when it malfunctions. They identified and isolated the T-cell receptor, a primary sentinel for the immune response. They learned how the body makes and selects an effective array of T cells that recognize and attack potentially harmful foreign proteins while leaving the body's own tissues alone. They discovered superantigens, virulent toxins that cause an overwhelming and disastrous immune response that occurs in maladies such as toxic shock syndrome and food poisoning.

Born in England, Marrack earned her doctorate of philosophy degree in biological sciences at Cambridge University. During her career, Marrack has published more than 450 peer-reviewed journal articles. She has been a member of the U.S. National Academy of Sciences since 1989, a fellow of the Royal Society in Great Britain since 1997 and was elected to National Women’s Hall of Fame in 2015. Marrack is also a member of American Academy of Arts and Sciences and the U.S. Institute of Medicine. Together with his husband, she has won numerous prestigious awards including the Louisa Gross Horwitz Prize and Wolf Prize in Medicine.