時間：2021年5月21日下午3:00

地點(diǎn)：武漢大學(xué)櫻頂老圖書館

主講人：王松靈教授 中國科學(xué)院院士

題目：醫(yī)學(xué)研究的感悟

主講人簡介：

王松靈，中國科學(xué)院院士，中國醫(yī)學(xué)科學(xué)院學(xué)部委員，教授、主任醫(yī)師。首都醫(yī)科大學(xué)副校長，中華口腔醫(yī)學(xué)會副會長，北京醫(yī)學(xué)會副會長，口腔健康北京實(shí)驗(yàn)室主任。 Oral Diseases及JOR副主編， 《醫(yī)學(xué)教育管理》主編、 《今日口腔》主編。發(fā)表論文239篇，以通訊作者在PNAS、EMBO J、Blood、Nat Commun等發(fā)表英文論文157篇。 第一完成人獲2003及2010年國家科技進(jìn)步二等獎兩項(xiàng)；獲威廉蓋茨（William J. Gies）獎、吳階平醫(yī)藥創(chuàng)新獎、中源協(xié)和生命醫(yī)學(xué)獎-成就獎、何梁何利科學(xué)與技術(shù)進(jìn)步獎；英國皇家外科學(xué)院（愛丁堡）Fellowship ad hominem。研究方向?yàn)橥僖合倥c牙再生研究。發(fā)現(xiàn)人細(xì)胞膜硝酸鹽轉(zhuǎn)運(yùn)通道及硝酸鹽對人體的重要保護(hù)作用；揭示牙發(fā)育新機(jī)制，研發(fā)牙髓干細(xì)胞新藥，成功實(shí)現(xiàn)生物性牙齒再生。

Brief Introduction of Professor Songling WANG

Songling WANG, D.D.S., Ph.D.

Appointments

? Academician, the Chinese Academy of Sciences

? Fellow, Academic Department of Chinese Academy of Medical Sciences

? Vice President, Capital Medical University

? Vice President, Chinese Stomatological Association

? Vice President, Beijing Medical Association

? Fellowship ad hominem the Royal College of Surgeons of Edinburgh (FRCS)

? Director, Beijing Laboratory of Oral Health, Beijing Municipal Government

Dr. Songlin Wang got DDS, PhD from Peking University, then works in Capital Medical University since 1989. Dr. Wang visited in Tokyo Medical and Dental University in 1991-1992 and worked in NIDCR, NIH during 1996-1998. Dr. Wang was honored by AADR/IADR 2007 William J. Gies Award for Biological Research and 2007 Cover of the Year Award. He also received two National Science and Technology Advancement Awards of China (second class) as first principle investigator in 2003 and 2010; Wu Jieping Medical Innovation Award ; Ho Leung Ho Lee Foundation Medicine Pharmacy Award Prize. Now he is associate editor of Oral Diseases and Journal of Oral Rehabilitation, Chinese Journal of Dental Research (in English), Chinese Journal of Stomatology, etc. He has authored more than 209 peer reviewed articles (117 in English) including PNAS, EMBO J, Blood, Nature Communications, and 16 review articles (11 in English), edited 8 books and 12 book chapters. He has national grants to support his research including National Key Basic Research Program of China (973), National High Technology Research Program of China (863), key grant of National Nature Science Foundation of China. As a supervisor, he has taught 69 PhD students, 20 Mater degree students and 18 post-docs. Major interests: Salivary gland research and tooth regeneration. The major scientific contribution including①Discovery of nitrate transporter Sialin (SLC17A5) and clinical functions of nitrate. They first discovered that parotid gland was an important organ that mediated metabolism and dynamic nitrate balance through the entero-salivary circulation of nitrate. Then they focused on this physiological phenomena and discovered Sialin (SLC17A5) functioned as a nitrate transporter in the plasma membrane of salivary gland acinar cells. Furthermore, they have been concentrating on the physiological function of nitrate and potential clinical application. They found that the protective effect of salivary nitrate could function against stress in human and rats. Dietary nitrate can prevent and rescue osteroprosis, irradiation damage to salivary glands, senescence-related decline in liver function, etc.②Salivary hypofunction restoration. His team aims to restore the salivary function through various methods. They have successfully achieved the alleviation of Sj?gren’s syndrome by transplantation of the allogeneic mesenchymal stem cells. Besides, by transferring adenoviral-mediated human aquaporin-1 cDNA into salivary gland, they alleviated and prevented salivary hypofunction. Their recent work showed that systemic rapamycin administration could also alleviate and prevent salivary hypofunction and intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model. ③Tooth and periodontal tissue regeneration. His team successfully regenerated a root/periodontal complex capable of supporting a porcelain crown, which showed biomimetic compressive strength, modulus of elasticity, and torsional force. They generated a swine model of periodontitis, then demonstrated that significant periodontal tissue could be regenerated by transplanting periodontal ligament stem cells (PDLSCs) into the periodontal defects in the swine model. Furthermore, they showed that both autologous and allogeneic dental pulp stem cells (DPSCs) can significantly regenerate periodontal tissues in miniature pig model and patients with periodontitis. They are developing dental pulp stem cells as a new drug of stem cells now.④Discovery of mammalian tooth replacement mechanism. They have used the miniature pig model to understand tooth development. They described the exact chronological stages of each tooth family and profiled stage-specific differential gene expression, DNA methylation and microRNA expression during deciduous and permanent dentition morphogenesis. Based on these new findings from the databases they established, they discovered that biomechanical stress regulates mammalian tooth replacement via the integrin b1-RUNX2-Wnt pathway.