時間：2022年9月21日（周三）下午16:00

地點：武漢大學櫻頂老圖書館

主講人：李勁松 研究員 中國科學院院士

題目：從克隆到半克隆—技術(shù)進步引領(lǐng)科學發(fā)展

主講人簡介：

李勁松，中國科學院院士，中國科學院分子細胞科學卓越創(chuàng)新中心研究員，細胞生物學國家重點實驗室主任。李勁松院士1993年畢業(yè)于江西農(nóng)業(yè)大學，獲學士學位；1996年畢業(yè)于揚州大學，獲碩士學位；2002年畢業(yè)于動物研究所，獲博士學位；2002年至2007年在洛克菲勒大學從事博士后研究；2007年8月起任生化與細胞所研究員。

李勁松院士從事干細胞與胚胎發(fā)育相關(guān)研究。率領(lǐng)團隊建立了小鼠孤雄單倍體胚胎干細胞（即“類精子干細胞”），證明其能代替精子使卵子受精產(chǎn)生健康小鼠（即“半克隆技術(shù)”），并利用類精子干細胞攜帶CRIPSR-Cas9文庫實現(xiàn)了小鼠個體水平的遺傳篩選；提出并推動基于類精子干細胞技術(shù)的基因組標簽計劃。研究成果2011年和2012年入選“中國科學十大進展”。以第一作者或通訊作者身份在Cell, Nature, Cell Stem Cell, Nature Cell Biology等雜志發(fā)表60余篇研究論文。

Brief Introduction of Professor Jinsong Li

Professor Jinsong Li is a principle investigator (PI) at Center for Excellence in Molecular Cell Science (CAS). He is a member of Chinese Academy of Sciences. Dr. Li obtained his PhD degree from Institute of Zoology, Chinese Academy of Sciences, in 2002 and followed by postdoctoral training at Rockefeller University before joining Shanghai Institute of Biochemistry and Cell Biology (SIBCB) in 2007. His research mainly focuses on stem cells and embryonic development. He has made fundamental contributions to the establishment of androgenetic haploid embryonic stem cells (also termed “sperm-like stem cells” or “artificial spermatids”) that can be used as sperm replacement for efficient production of semi-cloned mice (so called semi-cloning (SC) technology). Dr. Li has made great efforts to promote the applications of SC technology and shown that it can be used as a unique tool for genetic analyses in mice, including efficient generation of mouse models carrying defined point mutations related to human developmental defects; one-step generation mouse models that mimic multiple genetic defects in human diseases; and medium-scale targeted screening of critical genes or critical nucleotides of a specific gene involved in a developmental process. Most recently, Dr. Li launched and is promoting a huge project to tag every protein in mice based on sperm-like stem cell-mediated SC technology (genome tagging project, GTP), which may enable the precise description of protein expression and localization patterns, and protein–protein, protein–DNA and protein–RNA interactions in development/ aging, physiological and pathological conditions.